OP35 Suitability Of Preference Methods Across The Medical Product Lifecycle: A Multicriteria Decision Analysis

Introduction To understand the importance of preference methods criteria to stakeholders at each decision point in Medical Product Lifecycle (MPLC) and determine suitability commonly applied (Discrete Choice Experiment [DCE], swing weighting [SW], probabilistic threshold technique [PTT], Best-Worst Scaling case 1 [BWS1], 2 [BWS2]) for a given decision-point. Methods Nineteen an existing performance matrix were incorporated online survey industry, regulatory, health technology assessment (HTA) stakeholders. All relative weight based on SW ranking allocation task survey. Based this values, overall score was calculated method per critical along MPLC. Several sensitivity analyses conducted which adapted. Results In total 59 29 5 HTA representatives completed general, ‘estimating trade-offs between characteristics’, weights treatment characteristics’ important throughout all MPLC points, while other most only specific stages. Both BWS1 BWS2 seem equally suitable across DCEs during clinical development regulatory launch, PTT industry points. Sensitivity analysis showed substantial impact slight changes matrix. Conclusions With rapid research, matrices should continue be re-evaluated as more evidence accumulates. While DCE is elicitation method, also considered address needs Development evidence-based guidance documents designing, conducting, analyzing such could enhance their use.